![]() These protein products are truncated and frequently nonfunctional (e.g., cystic fibrosis). Ī nonsense mutation is when a nucleotide substitution results in a new stop codon, which includes UGA, UAA, and UAG (remember the mnemonic "U Go Away, U Are Away, and U Are Gone," respectively). Missense mutations have variable effects but can lead to a decreased or altered protein function (e.g., sickle cell disease). There are various types of mutations, such as silent, missense, nonsense, and frameshift mutations.Ī silent mutation is a nucleotide substitution that codes for the same amino acid therefore, there is no change in the amino acid sequence or protein function.Ī missense mutation is when a nucleotide substitution results in an amino acid change. ![]() It is noteworthy that not all DNA mutations will have an impact on protein synthesis or function. For example, a CGG repeat expansion in the FRM1 gene causes fragile X syndrome, while a fusion protein BCR-ABL results in chronic myeloid leukemia (CML). Otherwise, human disease is a result of a mixed assortment of insertions, deletions, duplications, inversions, expansions, fusions, and complex rearrangements. An example is sickle cell disease, where a single base-pair mutation results in glutamate to valine amino acid substitution. Single base-pair substitutions are the most common cause of human pathology. Mutagenesis is the driving force of evolution however, it can also lead to cancers and heritable diseases. Furthermore, molecular genetic techniques, such as polymerase chain reaction (PCR), have revolutionized how mutations are obtained and studied. ![]() DNA consists of nucleotides that contain a phosphate backbone, a deoxyribose sugar, and one of four nitrogen-containing bases (adenine, guanine, cytosine, and thymine ). DNA mutagenesis occurs spontaneously in nature or as a result of mutagens (agents with a predisposition to alter DNA). A mutation is a permanent and heritable change in genetic material, which can result in altered protein function and phenotypic changes. Mutagenesis is the process by which an organism's deoxyribonucleic acids (DNA) change, resulting in a gene mutation. ![]()
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![]() A quick way to gain market share and enter a competitive industry.Setting low prices can be a marketing tool raising brand awareness.Services like Amazon Prime which includes free tv programmes have been sold at a large discount to attract customers to sign up and get used to Amazon way of shopping. It has offered discounted delivery rates. Amazon has aimed at penetration pricing in many aspects of its business. European supermarkets Lidl and Aldi entered the market setting low prices – often lower than main rivals Tesco and Sainsbury’s – this enabled them to gain a growing market share.Īmazon prime delivery. The UK supermarket industry is very competitive, for a new rival to enter the market it will need to compete on price. ![]() But if penetration pricing is successful, then over time, it can slowly start to increase prices. The drawback of penetration pricing for a firm is that in the short-term it will make a loss or very low profit. If the firm sells a high quantity, they believe the marginal cost of production is £0.88, therefore, they can sell at £0.89 to try and take some market share from the existing brand. The existing brand sells at £1.99 which is a good profit margin, but they have strong brand loyalty. ![]() By setting eye-catching low prices, the firm hopes that it will be able to gain consumer awareness of the firm’s entrance into the market. Penetration pricing is also a marketing ploy. ![]() The aim of penetration pricing is to attract a loyal customer base through offering the most competitive price in the market and undercutting rivals and well-known brands. Penetration pricing is a strategy used by a firm who wishes to enter a new market and gain a high market share through selling at a low price. ![]() ![]() With so many years of features for project professionals in the desktop Project app, it’s understandable that it would take time to bring those to Project on the web (and it recently got a much-requested critical path view as well as custom fields). There’s also some frustration at the speed of development, which has kept some organizations interested in migrating to Project Online still using the desktop app. ![]() There’s still strong demand for Project, with plenty of feedback requests for advanced features from the desktop app like a consolidated view of Planner and Project tasks, resource planning, project baselines (to track whether a project stayed on target or got delayed) or being able to choose different options for dependencies between tasks. Including Project in the core Microsoft 365 subscription wouldn’t make sense either, he suggested, because “for some users the feature set will be more than they need (and will be getting bigger) so that they then find it too cumbersome.” Instead, Microsoft is looking to deliver parity so that Planner users who move on to Project don’t lose any of the features they’re used to-and so that people who are getting assigned tasks through both Planner and Project “don’t have to think about those tasks any differently-or go to different places to update their progress.” As Brian Smith, senior escalation engineer in the Project support team explained in an online discussion, Microsoft doesn’t want to “make Planner users pay for Project licenses when they only need some of the basic functions.” Planner is getting more powerful features -soon you’ll be able to create recurring tasks in Planner and use text formatting and insert images in task notes-but it’s not intended to be as powerful or as complex as Project. So, if you’re working with someone in another office or working remotely, the two eight-hour days you allocate to a task will correctly show up as three or even four days in the schedule if their timezone means their Tuesday and Wednesday office hours correspond to your Tuesday night to Thursday morning. Project on the web doesn’t have all those features, but it does have new ones, like understanding time zones. It’s included with Premium and Professional subscriptions to Project Online as the Project Online Desktop Client, using the cloud service instead of Project Server. There’s also still the desktop version of Project which has the full set of professional project management features. Microsoft talks about it as a “step up” from Planner, and it has a scheduling engine, so if you mark one task as being dependant on something else that has to be finished before you can start it, schedules will get updated automatically as you mark the first task finished or delayed. Project is an online service with web and mobile apps that’s aimed at the occasional and professional project manager. Windows 10 and 11 in S Mode: What Is It, and Should You Use It?ġ0 Best Project Management Software for Windows in 2023 How to Download and Install the Windows 11 23H2 Update Planner is designed for people with no project management expertise who still have to manage projects, or at least tasks being done by groups of people-even if you might not call that something as formal as a project. Microsoft 365: A side-by-side analysis w/checklist (TechRepublic Premium) ![]() That’s not because Microsoft plans to turn them into a single app or service, but to make it easier to use together if your needs get more complicated as a project develops. Microsoft Project and Planner come from the same team, share many technologies and have increasingly similar interface designs, with Planner getting more powerful tools while features from Planner show up in Project. ![]() Managing tasks and projects with a group of people? Microsoft has a lot of tools for task management (including To Do, Outlook tasks, Azure Boards for developers or building your own with Lists) but there are two overlapping offerings for team projects. Project will have the same option for starting a Teams chat about a specific task that Planner already has. Not everyone wants to be a project manager but Microsoft wants to make it less painful when team task management needs to get more formal. ![]() ![]() ![]() See the list of topics you need to study on our GED math page. Attending our online classes will also guide you comprehend how to use these formulas and you will have a high GED Math test score. You will receive incredibly detailed scoring results at the end of your GED Science practice test to help you identify your strengths and weaknesses. Take one of our many GED Science practice tests for a run-through of commonly asked questions. The best way to put these formulas to do is by taking our Math practice tests. Our completely free GED Science practice tests are the perfect way to brush up your skills. Remember, it’s not memorizing them that matters, but applying and understanding them. Also, it would be good to analyze the formulas and practice using them before the test. Use them to help you arrive at the correct answer. You have a formula sheet and a calculator during the test. Free GED Math Practice Test (questions, step-by-step solutions) to help you learn and review the math topics required for the GED. See if it is really the solution being presented to you. It includes +100 videos, +2000 problems and loads of information.Ĭompute twice before submitting your final answer. Quick Tips to Remember When Preparing for the GED Math TestĬheck our Math Blueprint Video Course covering every possible topic for GED Math. You must be able to demonstrate your skills in number sense and computation, algebraic expressions and functions, data analysis and statistics, and geometric measurement. Overall, the GED Math test checks your mastery of foundation math skills. The test questions are multiple choice as well as fill-in-the-blank, drag and drop, select an area, and drop-down. The questions focus on two content domains: algebraic problem-solving (55%) and quantitative problem solving (45%). The GED test is comprised of four separate content area tests: Mathematical Reasoning. The types of items included in the Math test is multiple-choice, drag-and-drop, hot spot, and fill-in-the-blank. Because you can see the formulas during the test, it only means that you want to focus on understanding how to apply them instead of just merely memorizing them. You may view the formula sheet here while answering our GED practice test for math. Along with the calculator, a formula sheet will also be provided on the day of the test. ![]() You have the option to bring your own TI-30XS calculator to solve the question during the test or you can use the on-screen calculator. Students will be permitted to use the calculator for part 2, which contains the remaining 41 questions. GED Practice Test - 50+ Free Exam & 1000s of Practice Questions. The beginning part, which contains the first five test questions, do not allow the use of calculators. Students will be given 115 minutes to complete the test. The GED Math test is a single section test with 46 questions. GRE vs GMAT – Significant Difference between GRE and GMAT. ![]() The math section revolves around algebra, graphs, geometry, and some basic math. Out of which forty are multiple-choice questions (MCQs) and the remaining ten involve grids. SAT Practice Tests & Free Online Questions There are a total of fifty questions in this portion that should be completed within a duration of ninety minutes.GED Reasoning Through Language Arts Practice Test. ![]() ![]() We’ve done the hard work for you and scoured the web for 14 of the loveliest fonts. Now that you’re well-versed in the various font types, it’s time to decide which will work for your wedding invitations. "They have a modern elegance and can be paired together to create contrast through different thicknesses of fonts.” They are excellent for digital invitations but also the most legible,” says Kentris. “Sans serif fonts are the cleanest letters, with no extra flourishes or feet. ![]() “There are two styles of serif fonts: more traditional, grounded in centuries-old styling, that feel like they belong in old history books, and a modern serif styling that is elevated borrows from current design trends still is grounded in tradition.” “Serif fonts are great for print design, as they have extra ‘feet’ as they are sometimes referred to, that help bridge the visual lines between each letter and make for better legibility overall,” says Kentris. “ are varied these days and can be a mix of modern calligraphy, where the letters are varied and feel more hand-drawn, to a traditional calligraphy style that looks closer to a script-style font,” says Kentris. “Many have lots of flourishes-the swooshes and extras around each letterform-which add to the ornate styling.” “Script fonts have a formal feeling and are grounded in traditional styling,” says Kentris. With that in mind, here are the main styles of font that you will be looking at when making the decision. If you’re new to the world of fonts, understanding the basics will help you find the ideal one for your invitations. ![]() Introducing Minted + Brides: Shop our exclusive collection of easy-to-customize wedding invitations, featuring wedding websites, invitation suites, and more! Types of Fonts to Consider for Your InvitationsĪhead of looking at some of the best wedding fonts, here’s a crash course in typography. ![]() ![]() Regarding automation, your accounts and other accounting tasks are managed and performed in the real world.Īs soon as the transaction happens, our offline accounting software records it in the company’s books. In other words, you get the facility to automate your accounting process. With the Vyapar offline accounting system, you can get automation advantages. The Vyapar app works efficiently and saves time during the accounting process. When the software has access to all financial details, maintaining records becomes not just simple but efficient. You can easily connect your bank accounts and software to other business processes. With the exceptional ability of automation, this tool helps businesses maintain books of accounts better. Vyapar is an offline accounting software powered by automation. Here’s why you should choose Vyapar for your accounting needs: Enhanced Efficiency Vyapar is one of the best offline accounting software available in the market. The accounting department can better record and analyse cash flow with a feature-rich dashboard. Using offline accounting software to manage cash is convenient and efficient. Therefore accounting for every note in and out of your business is necessary. ![]() Cash is a tangible asset and one of the most flexible ones. Managing and maintaining the cash flow of your business is one of the most challenging accounting jobs. Thus, you can restore it, even if it gets lost. Therefore, every account detail is saved on your cloud account. Offline accounting apps such as Vyapar are cloud-based. Using offline accounting, the least of your worries is losing your data. But since books of accounts are one of the most important documents, you must avoid losing them. Physical books of accounts are always prone to get damaged for multiple reasons. With manual bookkeeping, the chances of data loss are high. Therefore, one can also access the records online, despite worrying about the current location. Most offline accounting software is cloud-based. You can access your company’s financial data anytime with ease. With Offline Accounting Software, data accessibility becomes easy. You cannot neglect your attention to your books anymore. Nowadays, industries have changed so much that keeping an eye on your brand’s accounts is necessary. Automation saves time and makes your records of various data reliable. With automation, accounts can be maintained in real-time. Offline Accounting Software offers an automation facility, which reduces the risk of potential errors. ![]() Manual bookkeeping and account management aren’t just tedious but also prone to human errors. Imagine entering hundreds of transactions by hand in your books of accounts and or manually maintaining your accounts. The tool automatically prepares the return reports, which allows you to file the returns directly. Offline Accounting Tools bring convenience during tax calculation and filing. Moreover, manual maintenance of accounting can also become a pain when you file your returns. ![]() Keeping track of all the transactions and then calculating your debts manually is time-consuming. Taxes are a topic that gives nightmares to every business, no matter how successful. Here are some reasons to justify the importance: Simplifying Taxes Introducing offline accounting software is highly important for your business growth. In addition to automatic accounting, offline accounting software offers tools such as financial reporting, payroll, bill payments and invoicing. It can save time, especially in complex tasks such as bank reconciliation. The Vyapar Offline Accounting Software automatically fills in, stores, and analyses financial data for users. Offline accounting software, such as Vyapar, uses automated technology to record every financial transaction in real time. These transactions are integral to be recorded for accounting purposes to manage the company’s finances. In a business, a considerable number of transactions take place every day. It means accounts can be managed in real-time, whether the internet is accessible or not. But Vyapar is an online and Offline Free Accounting Software compatible with and without the internet. Most modern accounting tools are internet-based or connected to the cloud. The software records all the financial transactions of a business, making financial data accessible 24/7. As the name suggests, Offline Accounting Software is a tool used for bookkeeping and accounting. ![]() ![]() ![]() The 45°-45°-90° triangle, also referred to as an isosceles right triangle, since it has two sides of equal lengths, is a right triangle in which the sides corresponding to the angles, 45°-45°-90°, follow a ratio of 1:1:√ 2. This type of triangle can be used to evaluate trigonometric functions for multiples of π/6. ![]() Then using the known ratios of the sides of this special type of triangle: a =Īs can be seen from the above, knowing just one side of a 30°-60°-90° triangle enables you to determine the length of any of the other sides relatively easily. For example, given that the side corresponding to the 60° angle is 5, let a be the length of the side corresponding to the 30° angle, b be the length of the 60° side, and c be the length of the 90° side.: Thus, in this type of triangle, if the length of one side and the side's corresponding angle is known, the length of the other sides can be determined using the above ratio. In this type of right triangle, the sides corresponding to the angles 30°-60°-90° follow a ratio of 1:√ 3:2. The 30°-60°-90° refers to the angle measurements in degrees of this type of special right triangle. The perimeter is the sum of the three sides of the triangle and the area can be determined using the following equation: A = Examples include: 3, 4, 5 5, 12, 13 8, 15, 17, etc.Īrea and perimeter of a right triangle are calculated in the same way as any other triangle. In a triangle of this type, the lengths of the three sides are collectively known as a Pythagorean triple. If all three sides of a right triangle have lengths that are integers, it is known as a Pythagorean triangle. The altitude divides the original triangle into two smaller, similar triangles that are also similar to the original triangle. h refers to the altitude of the triangle, which is the length from the vertex of the right angle of the triangle to the hypotenuse of the triangle. In this calculator, the Greek symbols α (alpha) and β (beta) are used for the unknown angle measures. Their angles are also typically referred to using the capitalized letter corresponding to the side length: angle A for side a, angle B for side b, and angle C (for a right triangle this will be 90°) for side c, as shown below. ![]() The sides of a right triangle are commonly referred to with the variables a, b, and c, where c is the hypotenuse and a and b are the lengths of the shorter sides. In a right triangle, the side that is opposite of the 90° angle is the longest side of the triangle, and is called the hypotenuse. Right triangles, and the relationships between their sides and angles, are the basis of trigonometry. Related Triangle Calculator | Pythagorean Theorem Calculator Right triangleĪ right triangle is a type of triangle that has one angle that measures 90°. ![]() ![]() Icograms Designer empowers you to design powerful software architecture diagrams that combine software and real-world components for AI, IoT, robotics, cloud computing, augmented reality, With Icograms Designer, you can visually communicate the architecture of your advanced projects, facilitating better collaboration, decision-making, and understanding. Whether you're working on AI-powered applications, IoT ecosystems, robotics frameworks, cloud-based solutions, or augmented reality experiences, Icograms Designer provides the necessary features and assets to represent your technology stack effectively. Icograms Designer is a versatile tool that caters to a wide range of cutting-edge technologies.
![]() "Just because Susan Monica is different and strange and weird doesn't make her a murderer," another defense lawyer, Christine Herbert, told the jury.Īt one point during the six-day trial, Monica herself cross-examined sheriff's Detective Eric Henderson, who was the lead investigator in the case, despite having her own defense team. She said Delicino suffered three to four gunshot wounds to the head, but there was no evidence one way or another about the self-defense claim. Vance said she couldn't determine whether the ax blows came before or after Haney died. ![]() Some of his remains were found in plastic bags in her barn.Ī State Police forensic anthropologist, Veronica Vance, testified that Haney's legs had been chopped off with an ax, and the thigh bones showed signs of being gnawed by an animal. She later questioned whether he was alive when she shot him.ĭefense attorney Garren Pedemonte argued there was no concrete evidence to rebut Monica's claims that she shot Delicino in self-defense or to show that Haney was actually alive when Monica shot him. She said she came on him a month later as pigs were disemboweling him, and she shot him to ease his suffering. Monica told investigators Haney disappeared in the summer of 2013. ![]() She variously claimed that Delicino shot himself repeatedly in the head and also that she shot him in self-defense and he was eaten by her pigs before she buried his remains on her 20-acre farm in southern Oregon, Smith reminded jurors. Monica's changing stories about how she shot Delicino and Haney never matched the forensic evidence, Allan Smith, senior assistant deputy district attorney, told jurors in closing arguments. The case will be appealed, the defense said. Monica asked for sentencing as soon as the jury was dismissed, saying "it doesn't seem to matter." Prosecutors said Stephen Delicino, 59, was killed in 2012 and Robert Haney, 56, died in 2013. "It may sound harsh, but you are a cold-blooded killer," Barnack said. You valued pigs more than you value people. "You shot two people and fed them to your pigs," the judge told Monica, 66. The Jackson County jury found Susan Monica guilty of murdering two men about a year apart, then abusing their corpses by feeding them to the animals at her farm, The Medford Mail Tribunereported.Ĭircuit Judge Tim Barnack immediately sentenced Monica to a minimum 50 years in prison. (AP) Jurors spent only about an hour deliberating Tuesday before convicting an Oregon woman of killing two handymen and feeding their corpses to her pigs. You’ll find thicker crowds of tourists in the section of the bluff-top park by the Santa Monica Pier, so instead keep toward the northern Pacific Palisades-adjacent end.MEDFORD, Ore. If you only do one thingįor stunning views of the ocean and Santa Monica Mountains, Palisades Park is the spot. Thankfully, the area is served by Metro’s Expo Line, with a station only blocks from the beach. Actually getting to Santa Monica is a challenge for most car-bound Angelenos thanks to rush hour gridlock on the Pacific Coast Highway and notoriously terrible traffic on the 10 freeway (traffic heading west into Santa Monica eases up a bit by 10am, while eastbound traffic out of the city is already starting to crawl by 2pm). and Mar Vista to the east and Venice to the south. Though most Angelenos consider Santa Monica part of L.A., it’s technically a separate city, surrounded on all land-facing sides by Los Angeles neighborhoods: Pacific Palisades to the north Brentwood, West L.A. Meanwhile, northeast of downtown you’ll find posh spots along Montana Avenue. Venture southeast of the area and you’ll encounter a hip, more low-key stretch of shops and eateries along Main Street, continuing toward the Venice border near Rose Avenue. No matter where you are within that grid, walk toward the ocean and you’ll stumble upon Palisades Park and pathways to the Santa Monica Pier. You’ll find Santa Monica’s incredibly walkable downtown district roughly between Wilshire Boulevard, Lincoln Boulevard, Colorado Avenue and Ocean Avenue. You’ll find more than just a beach town, though there are plenty of things to do in Santa Monica without setting foot on the Pier or Third Street Promenade, from fresh dinners prepared straight from the farmers’ market to bars with a view. With the sandy beach on one side and lush mountains on another, it’s the essence of that postcard picture of Southern California’s coastline. ![]() ![]() Take a walk along the palm and eucalyptus-lined bluffs and it becomes obvious why tourists flock to Santa Monica. ![]() ![]() The sale price must be for the exact item you bought
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